A MUTANT OF TISSUE FACTOR PATHWAY INHIBITOR, DNA SEQUENCE AND USE FOR DETECTING THROMBOTIC DISORDERS

摘要

The invention relates to a novel mutant of tissue factor pathway inhibitor (TFPI) protein and its corresponding DNA sequence. The mutant can be found in humans who show or may show an increased risk of thrombotic diseases. By screening samples of human blood for said DNA or fragments of it, it is possible to predict a disposition of thrombotic disorders by which prophylactic application or measures can be initiated.