| 摘要 |
<p>A cell having a modified foreign chromosome (fragment) is constructed by transferring the foreign chromosome into a cell having a high homologous recombination efficiency by the microcell fusion method, marking a desired site of the foreign chromosome by the homologous recombination method, and inducing deletion and/or translocation at the marked site. A method for constructing a nonhuman animal having a modified foreign chromosome (fragment) by using the above procedure; and a modified animal, a recombinant chromosome (fragment) and an artificial chromosomal vector each obtained thereby.</p> |
