2,6-Disubstituted purine cyclic nucleotides

摘要

Compounds of structure WHEREIN X is Cl, F or Br and Y is Cl or Br, are prepared by diazotization of 2-amino-6-halo-9- beta -D-ribofuranosylpurine 3',5'-cyclic phosphates in the presence of an appropriate concentrated halogen-containing acid. The 2' hydroxyl of the subject compounds may be C1-C18 acylated. The compounds are useful, e.g., as intermediates in the production of biologically active analogs of adenosine 3',5'-cyclic phosphate (cyclic AMP) such as 2-chloroadenosine 3',5'-cyclic phosphate.