| 摘要 |
<p>The invention refers to a new procedure of preparation of alkyl substituted purine derivatives, specifically N7 and N9 alkyl purine derivatives, and to new compounds such as N7 alkyl derivatives exhibiting a potential biological, e.g. antiviral or antitumor activity. The new procedure enables a regionally selective attachment of a certain alkyl group to the site 7 or site 9 of purine and after having removed the protective group on a second nitrogen atom of the imidazole part of the molecule, a desired compound is obtained in a regionally selective way. According to this procedure, 9-benzyl guanine was successfully prepared from 7-benzyl guanine too. A new procedure is also described for preparation of famciclovir via intermediate penciclovir, which has been prepared according to the said procedure from 7-benzyl guanine.</p> |
