发明名称 Genetically engineered microorganisms and method for producing 4-hydroxybenzoic acid
摘要 The present invention pertains to a method for economical biofermentative production of 4-hydroxybenzoic acid (PHB) using genetically engineered E. coli. According to the invention, a plasmid is provided which controls the overexpression of chorismate pyruvate lyase, the bacterial enzyme which catalyzes the production of PHB from chorismate. Mutant E. coli selected with a unique two-step screening assay to overproduce chorismate have been transformed with this plasmid, providing a biocatalyst that efficiently converts glucose to PHB.
申请公布号 US6030819(A) 申请公布日期 2000.02.29
申请号 US19980161364 申请日期 1998.09.28
申请人 GENERAL ELECTRIC COMPANY 发明人 AMARATUNGA, MOHAN;LOBOS, JOHN HENRY;JOHNSON, BRUCE FLETCHER;WILLIAMS, ERIC DOUGLAS
分类号 C12N9/88;C12P7/42;(IPC1-7):C12P7/00;C12P7/02;C12P7/22;C12P7/40 主分类号 C12N9/88
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