发明名称 |
Photo-potentiation of cisplatin chemotherapy |
摘要 |
Methods disclosed herein capitalize on the discovery that DNA Structure Specific Recognition Proteins (SSRPs) can be induced to bind covalently to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents, by photo-irradiation with ultraviolet light. Methods and compositions based on this discovery are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs. Methods and compositions also are provided for potentiating cytotoxicity of a chemotherapeutic agent, particularly a cisplatin-type agent.
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申请公布号 |
US6030783(A) |
申请公布日期 |
2000.02.29 |
申请号 |
US19980015003 |
申请日期 |
1998.01.28 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
KANE, STEFANIE A.;LIPPARD, STEPHEN J. |
分类号 |
A61K45/06;(IPC1-7):C12Q1/68;C12N13/00;A01N59/16;A61K33/24 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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