| 摘要 |
PROBLEM TO BE SOLVED: To industrially efficiently obtain a physiologically active peptide useful for treating hypertension in a high yield by adding a protease and a raw material protein to a specific aqueous two-phase partition system and carrying out a peptide decomposition reaction. SOLUTION: A protease E such as thermolysin, etc., and a raw material protein S such as a maize protein, etc., are added to an aqueous two-phase partition system for forming two kinds of water-soluble polymers such as a polyethylene glycol, a dextran, etc. The raw material protein is subjected to a peptide decomposition reaction and a low-molecular weight physiologically active peptides P1 to Pn such as an angiotensin I converting enzyme, etc., formed by the decomposition reaction is taken out from one phase of the aqueous two-phase partition system to give the physiologically active peptides P1 to Pn. Preferably the peptide decomposition reaction is carried out in the polyethylene-rich phase and the formed peptides P1 to Pn are taken out from the dextran-rich phase.
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