发明名称 |
Non-nucleotide linking reagents for nucleotide probes |
摘要 |
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.
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申请公布号 |
US6031091(A) |
申请公布日期 |
2000.02.29 |
申请号 |
US19970908535 |
申请日期 |
1997.08.07 |
申请人 |
GEN-PROBE INCORPORATED |
发明人 |
ARNOLD, JR., LYLE J.;REYNOLDS, MARK A.;BHATT, RAM S. |
分类号 |
C07F9/24;C07H21/00;(IPC1-7):C07H21/00;C07F9/02 |
主分类号 |
C07F9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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