Acids and esters of diosmetin and pharmaceutical compositions containing them

摘要

Diosmetin acids and esters of formula (I), their enantiomers and salts are new. R2, R4, R6 = H, 1-5C alkyl, CH2CH=CH2, CH2C(CH3)=CH2, CH2CH=C(CH3)2, CH2CH2CH(CH3)2, 2,2-dimethyl-1,3-dioxolan-4-ylmethyl, CH2CH(OH)CH2OH or ACOOR8; A = 1-3C hydrocarbon chain (optionally substituted by methyl or OH); R8 = H or 1-5C alkyl; R3, R5 = H, CH2CH2CH3, CH2CH=CH2, CH2CH(CH3)2, C(CH3)2CH=CH2, C(CH3)2CH2CH3, CH2C(CH3)=CH2 or COCH3 R1, R7 = H, CH2CH2CH3, CH2CH=CH2, CH2CH=C(CH3)2, tert.-butyl, CH2CH2CH(CH3)CH3, CH2C(CH3)=CH2 or CH2CH(CH3)2 provided that if one or two of R2, R4, and R6 = ACOOR8, then at least one of the remaining R1-R7 is not H.