| 摘要 |
PROBLEM TO BE SOLVED: To produce a substituted piperidine epoxide useful for efficiently synthesizing a renin inhibitor by epoxidizing a specific compound. SOLUTION: By epoxidizing a compound of formula I [A is arylene; R1 is CR3R4R5 (R3 is H; R4 is an aryl; R5 is an alkyl, an aryl or the like; C* is asymmetric carbon atom); R2 is an O-alkyl, an O-cycloalkyl, an O-aryl or the like] or its salt a compound of formula II is obtained. The compound of formula I is e.g. (1R,6R)-6-(4-benzyloxy-phenyl)-3-[(R)-1-phenyl-ethyl]-7-oxa-3-aza- bicyclo[4.1.0]heptane or the like. The compound of formula II is a new substance and is e.g. (3R,4S,5S)-4-[4-(3-benzyloxy-propoxy)-phenyl]-5- ethoxy-3-(naphthalen-2-ylmethoxy)-piperidine. |
