PIPERAZINE DERIVATIVES

摘要

1. A compound of the formula: or fumaric acid salt thereof. 2. The compound of claim 1, which is the compound of the formula: 3. A process for preparing a compound of the formula: or fumaric acid salt thereof, which comprises (1) reacting a compound of the formula: or its reactive derivative at the carboxy group or a salt thereof with a compound of the formula: or its reactive derivative at the amino group or a salt thereof to give a compound of the formula: or fumaric acid salt thereof, or (2) reacting a compound of the formula : or a salt thereof other than fumaric acid salt thereof with fumaric acid to give a compound of the formula: 4. A pharmaceutical composition comprising a compound of claim 1 as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. 5. A method for treating or preventing Tachykinin-mediated diseases which comprises administering an effective amount of a compound of claim 1 to a human being or animals. 6. A compound of claim 1 for use as a medicament. 7. Use of a compound of claim 1 for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases. 8. A compound of the following general formula: wherein R<1> is trihalo(lower)alkyl, R<2> is trihalo(lower)alkyl, R<3> is indolyl(lower)alkyl, in which R<5> is hydrogen or lower alkoxycarbonyl, R<6> is hydrogen or lower alkanoyl, R<7> is hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkoxy(lower)alkanoyl, cyclo(lower)alkylcarbonyl, aroyl or lower alkylsulfonyl, or its pharmaceutically acceptable salt.