Calcitriol derivatives and their uses

摘要

A vitamin D derivative providing for the gradual in vivo release of a biologically active vitamin D compound and thereby regulating the in vivo availability and activity profile of the biologically active vitamin D compound, having the structure 1 Where R5 and R6 represent hydrogen, or taken together R5 and R6 are methylene R is represented by the structure 2 where Z is selected from various hydrocarbon groups with provisos to exclude prior art. Also claimed is a method of regulating the activity profile of a vitamin D compound where the hydroxy group at carbon 25, and a selected acyl group or a hydrocarbyloxycarbonyl group attached to the oxygen of the hydroxy group at carbon 25 will provide a modified vitamin D derivative that will prolong the in vivo activity profile of the vitamin D compound.