| 摘要 |
Pyridothiadiazine and pyridothiazine compounds of formula (I) and their salts are new: B = NR5 or CR5R6; R5, R6 = H, OH, 1-6C alkoxy or 1-6C alkyl, 3-6C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl optionally mono- or poly-substituted; or R4+R5 = bond; D = -S(O)2- or -S(O)-; or D-B = -S(O)(R10)=N-; R10 = 1-6C alkyl or aryl or heteroaryl optionally mono- or poly- substituted; R1 = H, OH, 1-6C alkoxy or 1-6C alkyl, 3-6C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl optionally mono- or poly- substituted; R4 = H or R4 + R1 = bond; R2= H, OH, 1-6C alkoxy or 1-6C alkyl, 3-6C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl optionally mono- or poly- substituted; R3 = e.g. R11, OR11, -C(=X)R11, -NR11R12, bicycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl optionally mono- or poly-substituted, or 1-6C alkoxycarbonyl etc.; or NR2R3 = 3-12 membered mono- or bicyclic system in which one or more of the C atoms may be replaced by N, O or S and the rings are optionally substituted; R11 = H, 3-6C cycloalkyl, 3-6C cycloalkyl(1-6C)alkyl (the cycloalkyl group being optionally mono- or poly-substituted), a 3-6 membered saturated ring system comprising one or more N, O or S atoms or 1-18C alkyl optionally mono- or poly- substituted; X = O or S; R12 = H, 1-6C alkyl, 2-6C alkenyl or 3-6C cycloalkyl optionally mono- or poly- substituted; or NR11R12 = 3-12 membered mono- or bicyclic system in which one or more of the C atoms may be replaced by N, O or S and the rings are optionally substituted; A forms a pyridine ring of e.g. formula (c) or (d); R7-R9= e.g. H, halo, 1-12C alkyl, 3-6C cycloalkyl, OH, 1-6C alkoxy(1-6)alkyl, NO2, NH2, CN, cyanomethyl, perhalomethyl, 1-6C mono- or di-alkylamino, sulphamoyl, 1-6C alkylthio, 1-6C alkylsulphonyl, 1-6C mono- or di-alkylaminocarbonyl; 1-6C mono- or di-alkylaminothiocarbonyl, ureido, carboxy(1-6C)alkyl, acyl, aryl, arylalkyl, aryloxy, (1,2,4-oxadiazol-5-yl)- or (1,2,4-oxadiazol-3-yl)-(1-6C)alkyl etc.; or a 5 or 6 membered N containing ring optionally substituted; with proviso. |
