REGULATING METABOLISM BY MODIFYING THE LEVEL OF TREHALOSE-6-PHOSPHATE

摘要

PURPOSE: A method for regulating a metabolism is provided to introduce or to inhibit the enzymes trehalose phosphate synthase (TPS) being capable of forming T-6-P and trehalose phosphate phosphatase (TPP) which degrades T-6-P into trehalose. CONSTITUTION: The invention lies in the field of regulation of carbon flow in the metabolism of the cell. It has been found that induction of a change in the intracellular availability of the saccharide trehalose-phosphate (T-6-P) induces modifications of the development and/or composition of cells, tissue and organs in vivo. These changes can be induced by introducing or inhibiting the enzymes trehalose phosphate synthase (TPS) which is capable of forming T-6-P and trehalose phosphate phosphatase (TPP) which degrades T-6-P into trehalose. The carbon flow through the glycolysis will be stimulated by a decrease in the intracellular level of T-6-P.