SUSPENSION OF SPARINGLY WATER-SOLUBLE ACIDIC DRUG

摘要

PURPOSE: A suspension of non-steroidal anti-inflammatory analgetic agent of a sparingly water-soluble acidic drug is provided to be safe for a long period and to be highly dissolvable. CONSTITUTION: A suspension of a sparingly water-soluble acidic drug especially, a non-steroidal anti-inflammatory analgetic agent, which is stable for a prolonged period of time and is highly dissolvable; and a process for simply and easily producing the suspension. This suspension has a pH value of 2 to 5 and comprises a sparingly water-soluble acidic drug whose average particle size ranges from 1 to 15 micrometers, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water, optionally, together with an inorganic powder having an average particle size of 1 to 15 micrometers This process is characterized by carrying out pulverization and dispersion of sparingly water-soluble acid drug, a polyglycerol fatty acid ester, a water-soluble polyhydricalcohol and water by means of a pulverizer comprising a main shaft adapted to rotate in a casing and a plurality of layshafts adapted to revolve in relationship interlocked with the rotation of the main shaft, each of the layshafts being fitted with a multiplicity of annular grinding media.