| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound useful in treating or preventing central nervous system disorders. SOLUTION: This new compound is shown by formula I (R1 is H; R2 is H, trifluoromethyl or the like; R3 is H or amino; Z is pyrimidin-4-yl, pyridin-4-yl, pyridin-2-yl, phenyl or the like; R4 and R5 are each H, a halogen, cyano or the like; (n) is 2-4; R6 and R7 are each H or a lower alkyl; when Z is pyrimidin-4-yl, R4 is different from R5; when Z is pyridin-2-yl, R is not a lower alkyl; when Z is phenyl, one of R4 and R1 to R3 is not H), e.g. [4-(4- aminobenzenesulfonyl)-6-bromopyridin-2-yl]-dimethylamine. The compound of formula I is obtained, for example, by oxidizing the sulfanyl group of a compound of formula II into sulfonyl group through reaction with an oxidizing agent such as NAIO4 or m-chloroperbenzenecarboxylic acid. |
