Arylpyridazinoner som biosynteseinhibitorer av prostaglandin endoperoksidase H-syntase

摘要

The pyridazinon compounds are selective inhibitors of cyclooxygenase (COX), in particular of cyclooxygenase-2 (COX/2), COX-2 - inducible isoform which is related to the respective inflammation, as opposite to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important enzyme in many tissues, including the gastrointestinal tract and in the kidneys. The selectivity of the COX-2 compounds reduces to a minimum the unwanted side effects in the gastrointestinal tract and in the kidneys observed in the so-far knowm nonsteroid antiphlogistic medicaments.