发明名称 |
Rna targeted 2'-modified oligonucleotides that are conformationally preorganized |
摘要 |
2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries. |
申请公布号 |
AU5121399(A) |
申请公布日期 |
2000.02.21 |
申请号 |
AU19990051213 |
申请日期 |
1999.07.21 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MUTHIAH MANOHARAN;VENKATRAMAN MOHAN;HERB BOSWELL |
分类号 |
C07H21/00 |
主分类号 |
C07H21/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|