| 摘要 |
The present invention provides compounds that block calcium channels and have the Formula I:and pharmaceutically acceptable salts, esters, and pro-drugs thereof, whereinR1 and R2 are independently H, phenylcyclopentylcarbonyl, C1-C7 alkyl, cyclohexylmethyl, benzyl, C1-C5 alkylbenzyl, or C1-C5 alkoxybenzyl,A is -C(O)- or -CH2-;R3 is H or -CH3;R4 is C1-C4 alkyl or piperidin-1-ylethyl;R5 is phenyl-(CH2)n-, C1-C4 alkylphenyl-(CH2)n-, or halophenyl-(CH2)n-; andn is 1 or 2.The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cerebral ischemia, head trauma, and epilepsy. |
