| 摘要 |
A method and apparatuses are disclosed for determining an anticoagulant therapy factor (ATF), a corrected anticoagulant therapy factor (CATF), and a modified anticoagulant therapy factor (MATF), all selectively used for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. The anticoagulant therapy factor (ATF), the corrected anticoagulant therapy factor (CATF), and a modified anticoagulant therapy factor (MATF) are based upon disclosed methods for determining the fibrinogen transformation rate (FTR) which, in turn, is dependent on a maximum acceleration point for fibrinogen (FBG) conversion. The ATF, CATF, and MATF quantities are also based upon the prothrombin time (PT), but have no need for the difficulty to obtain prior art International Normalized Ratio (INR) and International Sensitivity Index (ISI) parameters. The International Normalized Ratio (INR) was created to relate all species' clotting material to human clotting material. The AFT, CATF, and MATF quantities embody only human clotting material. The ATF, CATF, and MATF quantities and International Normalized Ratio (INR) are, hereby, species specific and provide the same results. |
