SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A.BETA. PROTEIN PRODUCTION

摘要

This invention relates to novel lactams of Formula (I) or a pharmaceutically acceptable salts or prodrug thereof, having drug and bio-affecting propertie s, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, th e present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome .