NEW SUBSTITUTED AMIDES, THEIR PRODUCTION AND THEIR USE

摘要

The invention relates to cysteine protease inhibitors of the general formula (I), in which A is -(CH2)p-R<1>, where R<1> can be pyrrolidine, morpholine, piperidine, -NR<5>R<6> and formula (a) and p can be 1 or 2; B can be possibly substituted phenyl, pyridyl, pyrimidyl and pyridazyl; D is a bond, -(CH2)m-, -CH=CH-, -CC-; R<2> is chlorine, bromine, fluorine, alkyl, NHCO alkyl, NHSO2 alkyl, NO2, -O-alkyl and NH2; R<3> is an alkyl which can carry a possibly substituted phenyl ring, indolyl ring and cyclohexyl ring; and Y is phenyl, pyridine, pyrimidine and pyrazine; R<4> is hydrogen, COOR<9> and CO-Z, where Z is NR<10>R<11> and and formulae (b), (c), (d); n is 0, 1 or 2 and m is 0, 1, 2, 3 or 4.