INDOLDERIVATE ALS 5-ALPHA-REDUCTASE-1 INHIBITOREN

摘要

PCT No. PCT/EP94/02563 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 2, 1994 PCT Pub. No. WO95/05375 PCT Pub. Date Feb. 23, 1995A compound of formula (I): and the pharmaceutically acceptable base salts thereof, wherein: R is CO2R12 where R12 is H or a biolabile ester-forming group, or R is tetrazol-5-yl, and either (a) R1 is and R2 is F, Cl, Br, I, CH3 or CF3, or (b) R1 is C3-C6 alkyl and R2 is C2-C4 alkyl, useful as steroid 5- alpha -reductase inhibitors.