摘要 |
<p>Nucleosidic monomers and oligomeric compounds prepared therefrom are provided which have increased nuclease resistance, substituent groups (such as 2'-aminooxy groups) for increasing binding affinity to complementary strand, and regions of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.</p> |
申请人 |
ISIS PHARMACEUTICALS, INC.;MANOHARAN, MUTHIAH;COOK, PHILLIP, DAN;PRAKASH, THAZHA, P.;KAWASAKI, ANDREW, M. |
发明人 |
MANOHARAN, MUTHIAH;COOK, PHILLIP, DAN;PRAKASH, THAZHA, P.;KAWASAKI, ANDREW, M. |