发明名称 |
PROCESS FOR PREPARING N,N,6- TRIMETHYL-2 -(4-METHYLPHENYL)- IMIDAZO-[1,2-A] -PYRIDINE-3- ACETAMIDE AND SALTS THEREOF |
摘要 |
The process comprises reducing the hydroxyester of formula (X) by making it react in DMF successively with an imine salt of formula (XIII) formed "in situ" with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducer in order to form the ester of formula (XII) which is then reacted with dimethylamine in a polyhydroxylated solvent medium in appropriate temperature conditions.
|
申请公布号 |
WO0008021(A2) |
申请公布日期 |
2000.02.17 |
申请号 |
WO1999ES00250 |
申请日期 |
1999.08.04 |
申请人 |
QUIMICA SINTETICA, S.A.;LABRIOLA, RAFAEL |
发明人 |
LABRIOLA, RAFAEL |
分类号 |
A61K31/415;A61K31/435;C07D471/04;(IPC1-7):C07D471/00 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|