发明名称 |
OLIGOMERS WHICH INHIBIT EXPRESSION OF COLLAGEN GENES |
摘要 |
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen- gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide or a ribonucleotide, preferably binds in the antiparall el orientation to the polypurine strand of a polypurine-polypyrimidine region o f the promoter region of a mammalian .alpha.1(I) collagen gene.
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申请公布号 |
CA2339348(A1) |
申请公布日期 |
2000.02.17 |
申请号 |
CA19992339348 |
申请日期 |
1999.08.06 |
申请人 |
GUNTAKA, RAMAREDDY V. |
发明人 |
KOVACS, ATTILLA;KANDALA, JAGANNADHACHARI;GUNTAKA, RAMAREDDY V.;WEBER, KARL T. |
分类号 |
A61K38/00;C07H21/00;C07H21/04;C12N15/113;C12N15/63;C12N15/85;C12Q1/68;(IPC1-7):C12Q1/68;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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