COMPOSITIONS AND METHODS FOR MODULATING PROTEOLYTIC DEGRADATION OF INTRACELLULAR TARGETS

摘要

A target-specific binding protein inactivated an exemplary glucose-6-phosphate dehydrogenase (G6PD) intracellular target by a mechanism involving proteosomal degradation. Phage-display libraries of recombinant binding proteins in which sequences for delivering binding proteins to proteosomes and modulating the rate of proteolysis also are disclosed. Methods of inactivating intracellular targets using the recombinant binding proteins are also disclosed.