发明名称 |
LATENCY-ACTIVE REGULATORY SEQUENCES OF HERPESVIRUSES AND LATENCY-INACTIVE HERPESVIRUS FOR GENE TRANSFER |
摘要 |
A mutant herpesvirus has inactivating (preferably deletion) mutations at the locus of both native copies of the latency-active regulatory sequences. The resulting virus can be used as a latency-inactive virus as the basis of the vectors for gene delivery, as a helpervirus for production of amplicons, and as a base virus mutant for the construction of mutant virus vectors carrying synthetic latency-active regulatory sequences. Also described are synthetic/semisynthetic latency-active regulatory sequences and their use in CNS and other cells.
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申请公布号 |
CA2337963(A1) |
申请公布日期 |
2000.02.17 |
申请号 |
CA19992337963 |
申请日期 |
1999.08.02 |
申请人 |
CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED |
发明人 |
LACHMANN, ROBIN HENRY;EFSTATHIOU, STACEY |
分类号 |
C12N15/09;A61K31/711;A61K35/76;A61K48/00;A61P43/00;C12N7/01;C12N7/04;C12N15/869;C12R1/93;(IPC1-7):C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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