PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-[6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL]ACETIC ACID DERIVATIVES

摘要

A process for the preparation of optically active 2-6-(hydroxymethyl)-1,3-dioxan-4-yl!acetic acid derivatives, which comprises subjecting an enolate prepared by reacting an acetate ester derivative with either a base or a zerovalent metal to reaction with a hydroxybutyric acid derivative at -30 ~C or above to thereby obtain a hydroxyoxohexanoic acid derivative, reducing this hydroxyoxohexanoic acid derivative with a microorganism into a dihydroxyhexanoic acid derivative, treating this dihydroxyhexanoic acid derivative with an acetal-forming reactant in the presence of an acid to thereby obtain a halomethyldioxanylacetic acid derivative, acyloxylating this halomethyldioxanylacetic acid derivative with an acyloxylating agent into an acyloxymethyldioxanylacetic acid derivative, and subjecting this acyloxymethyldioxanylacetic acid derivative to solvolysis in the presence of a base.