| 摘要 |
1,180,268. Anti-inflammatory &c. compositions. IMPERIAL CHEMICAL INDUSTRIES Ltd. 23 Aug., 1968 [26 Sept., 1967], No. 43677/67. Heading A5B. [Also in Division C2] Pharmaceutical compositions having antiinflammatory analgesic and antipyretic activity comprise compounds of formula and their pharmaceutically acceptable salts, wherein Het is a thiazole, isothiazole, oxazole, isoxazole, pyrrole, thiophene, furan, pyridine or pyrimidine ring, X is H or C 1-3 alkyl or alkoxy, Y is Ph optionally mono- or di-halogenated or p-CF 3 -substituted, and Z, which is attached to a ring-position non-adjacent to Y, is CR<SP>1</SP>R<SP>2</SP>CH 2 OR<SP>3</SP>, wherein R<SP>1</SP> and R<SP>2</SP> are each H or C 1-3 alkyl, and R<SP>3</SP> is H, C 1-4 alkyl, C 1-5 alkenoyl, benzoyl, carboxybenzoyl, alkanoyloxybenzoyl, dialkylcyclohexyloxyalkanoyl (up to C 12 ), PhNHCO or Y-Het<SP>1</SP>-CR<SP>1</SP>R<SP>2</SP>CO (where Het<SP>1</SP> is methylpyridyl, methoxypyrimidyl or Het, and CR<SP>1</SP>R<SP>2</SP>CO is attached to a ring- position of Het<SP>1</SP> non-adjacent to Y), but excluding 5-(2-hydroxyethyl)-4-methyl-2-phenylthiazole, 3-(2-hydroxyethyl)-5-phenylisoxazole and 5-(2-hydroxyethyl)-4-methyl-2-phenyloxazole and their salts. The compositions, which may be administered orally, rectally, topically or by injection, may contain additionally (i) in general, aspirin, paracetamol; codeine, chloroquine, phenylbutazone, oxyphenbutazone, indomethacin, mefenamic acid, flufenamic acid, ibufenac or predrisolone, (ii) for oral administration, homatropine methyl bromide or Al (OH) 3 , and (iii) for topical application, toluzoline, adrenaline, amethocaine, copsicum, sulphoamide, neomycin, hydroxyquinoline, promethazine or methyl nicotinate.
|
