DEPSIPEPTIDE DERIVATIVES BEARING PIPERAZINONE RINGS

摘要

Novel depsipeptide derivatives bearing piperazinone rings in the molecule, represented by general formula (1) wherein X1 is N(R4)-CO, N(R5)-CH2, CH2-CO, CH2-CH2, CH=CH, CH2-CH(OH) or CH(OH)-CH(OH); R1 is C5-C20 alkyl or alkoxy(C5-C15)alkyl(C1-C4); R2 to R5 are each hydrogen or C1-C6 alkyl; and A is (2), (3) or (4): -X2-CH(R11)-X3-CH(R12)-NH-R13. These derivatives exhibit apolipoprotein E production accelerating activities, thus being useful as remedies for nerve injury, dementia and hyperlipidemia.