HERPESVIRAL VECTORS FOR GENE DELIVERY

摘要

A mutant herpesvirus in which (a) an early gene encoding a function required for expression of late gene products has been inactivated, e.g. by deletion; and in which (b) a viral gene essential for production of infectious new vir us particles has been inactivated, preferably by deletion; and in which (c) a gene to be delivered to a target cell has been inserted together with regulatory elements for its expression in a target cell, can be used as a ge ne delivery vector for gene delivery e.g. to central nervous system cells.