发明名称 |
Process for the synthesis of Diricinoleylphospatidylcholine |
摘要 |
<p>Diricinoleylphosphatidylcholine (I) in an optically active form is obtained with good yields and a high purity by means of a process which comprises: a) esterifying the terminal carboxylic group of ricinoleic acid (III) with an alcohol having from 1 to 4 carbon atoms to give the corresponding ester having formula (IV); b) protecting the hydroxylic group of the ester of ricinoleic acid (IV) with a protecting group removable under bland operating conditions and isolating the ester of ricinoleic acid of which the hydroxylic group (V) is protected; c) hydrolyzing the ester of ricinoleic acid of which the hydroxylic group (V) is protected and isolating the ricinoleic acid of which the hydroxylic group (VI) is protected; d) acylating L- alpha -glycerophosphatidylcholine (II) with an imidazolic or triazolic derivative of the compound having formula (VI) and isolating the diricinoleylphosphatidylcholine of which the hydroxylic group (VII) is protected; e) removing the protecting group from the hydroxylic group of the compound having formula (VII); and finally f) recovering and purifying the compound having formula (I) by means of chromatography.</p> |
申请公布号 |
EP0979825(A1) |
申请公布日期 |
2000.02.16 |
申请号 |
EP19990202512 |
申请日期 |
1999.07.30 |
申请人 |
METAPONTUM AGROBIOS S.C.R.L. |
发明人 |
BORSOTTI, GIAMPIETRO;BATTISTEL, EZIO;CELLINI, FRANCESCO;IANNACONE, RINA |
分类号 |
C07F9/10;C12P7/64;(IPC1-7):C07F9/10 |
主分类号 |
C07F9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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