PROCESS FOR THE SEPARATION OF TETRAHYDROPYRIMIDIN DERIVATIVES

摘要

Ectoin and hydroxyectoin produced by cultured Halomonas bacteria can be separated whilst in aqueous solution using an acidic zeolite. The ectoin is absorbed, while the hydroxy compound remains in solution. Separating tetrahydropyrimidine derivatives from their corresponding hydroxy compounds when in aqueous solution, comprises contacting the solution with an acidic zeolite at pH 1.0-7.0 (the zeolite has a modulus of 15-1000). The hydroxy compounds remain in solution, while the tetrahydropyrimidine compounds are absorbed by the zeolite, and can be desorbed by contacting with a solution of an organic base at pH of at least 8.0.