| 摘要 |
The present invention relates to novel guaiacoxypropanolamine derivatives of formula (I): wherein R is CH2CH=CH2, CH=CHCOOC2H5, CH=CHCH3, CH2NHCO(CH2)7CH3; R3 is OH, OCH3, NHCH2CH3OCH3, CHR6; R4 is OCH3, OC2H5, CHR6; R6 is C1-C6 saturated alkyl, C1-C6 unsaturated alkyl; R2 is (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI). The said compounds of formula (I) have alpha / beta -adrenergic blocking activity. The invention further relates to pharmaceutical composition comprising compound of formula (I) and pharmaceutical acceptable vehicle. The composition also has alpha / beta -adrenergic blocking activity, and is useful in the treatment of acute hypertension. |
