发明名称 |
Chemiluminescent 1,2-dioxetanes |
摘要 |
Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T1/2 kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.
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申请公布号 |
US6022964(A) |
申请公布日期 |
2000.02.08 |
申请号 |
US19970904847 |
申请日期 |
1997.08.01 |
申请人 |
TROPIX, INC. |
发明人 |
BRONSTEIN, IRENA;EDWARDS, BROOKS;SPARKS, ALISON |
分类号 |
C07D321/00;C07D327/06;C07F9/02;C07F9/06;C07F9/28;C07H19/04;(IPC1-7):C07D321/00 |
主分类号 |
C07D321/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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