发明名称 |
Method for producing a microparticle |
摘要 |
This invention provides a method for producing a microparticle which comprises pulverizing a solid preparation comprising a compound represented by the formula: wherein ring A is an optionally substituted benzene ring; R is a hydrogen atom or an optionally substituted hydrocarbon group; B is an optionally esterified or amidated carboxyl group; X is -CH(OH)- or -CO-; k is 0 or 1; and n is 0, 1 or 2 or a pharmaceutically acceptable salt thereof and a biodegradable polymer of alpha -hydroxycarboxylic acid in the presence of a pulverizing auxiliary, which can provide microparticles which are less adhesive and involve less aggregation and are thus excellent in drug entrapment ratio and control of drug-release in a desired particle size.
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申请公布号 |
US6022564(A) |
申请公布日期 |
2000.02.08 |
申请号 |
US19990260797 |
申请日期 |
1999.03.01 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
TAKECHI, NOBUYUKI;NONOMURA, MUNEO;HIGUCHI, SHIGEHIRO;BEPPU, TOSHIHARU |
分类号 |
A61K9/16;A61K31/38;A61K31/382;A61K31/67;B02C23/06;(IPC1-7):B02C23/06 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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