| 摘要 |
The present invention relates to a vaccine for generating protective immunity against Helicobacter infection in mammalians comprising a polyaminoacid preparation including epitopes exhibited by a Lactobacillus-derived urease in combination with a pharmaceutically acceptable carrier or diluent. The polyaminoacid preparation comprises a purified Lactobacillus fermentum urease, Lactobacillus reuteri urease or subunits thereof. In addition, the present invention relates to a process for assaying protective immune response in mammalians infected with Helicobacter organism which comprises determining the presence of antibody reactive with epitopes exibited by a urease endogenous to said Lactobacillus organism within a sample collected from gastric route of said mammalians. |
