The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 1A2 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 1A2 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 1A2, and in methods of measuring p450 1A2 levels in individuals relative to p450 1A2 levels in a control population.
申请公布号
WO0004864(A2)
申请公布日期
2000.02.03
申请号
WO1999US16362
申请日期
1999.07.19
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;GELBOIN, HARRY, V.;GONZALEZ, FRANK, J.;YANG, TIANG, J.
发明人
GELBOIN, HARRY, V.;GONZALEZ, FRANK, J.;YANG, TIANG, J.