摘要 |
The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Morever, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides or peptides to the mammal.
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申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;AHARONI, RINA;TEITELBAUM, DVORA;ARNON, RUTH;SELA, MICHAEL;FRIDKIS-HARELI, MASHA;STROMINGER, JACK, L. |
发明人 |
AHARONI, RINA;TEITELBAUM, DVORA;ARNON, RUTH;SELA, MICHAEL;FRIDKIS-HARELI, MASHA;STROMINGER, JACK, L. |