MONOCYCLIC beta -LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME

摘要

Chymase inhibitors and cytokine production inhibitors containing compounds represented by general formula (I), prodrugs of the same, pharmaceutically acceptable salts thereof or hydrates of them, wherein A is -CO-, -CONH- or the like; R<1> is optionally substituted lower alkyl, optionally substituted aryl or the like; R<2> and R<3> are each independently hydrogen, optionally substituted lower alkyl or the like; B is -S-, -O- or the like; and R<4> is optionally substituted aryl or the like.