发明名称 |
METHODS AND COMPOSITIONS FOR THE DETERMINATION OF PROTEIN FUNCTION AND IDENTIFICATION OF MODULATORS THEREOF |
摘要 |
The present invention provides libraries of tag dominant-negative elements (TDNE) and methods enabling the identification of specific TDNEs that act as dominant-negative elements on a target protein of interest. The present invention further relates to the use of such TDNEs and dominant-negative elements for the identification of protein-protein interactions, and the determination of a target protein's biological activity and function. Furthermore, the present invention relates to the development of means, including small molecule compounds, for disrupting the target protein's biological function and activity.
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申请公布号 |
CA2335392(A1) |
申请公布日期 |
2000.02.03 |
申请号 |
CA19992335392 |
申请日期 |
1999.07.23 |
申请人 |
SMALL MOLECULE THERAPEUTICS, INC. |
发明人 |
KHAZAK, VLADIMIR;MENZEL, ROLF |
分类号 |
C12N15/09;C07K7/00;C07K14/47;C07K19/00;C12N15/10;C12Q1/02;C12Q1/68;C40B40/02;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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