| 摘要 |
<p>Disclosed are novel dihydroepiandrosterone derivatives, preparation methods thereof, and prophylactic and curing agents against osteoporosis. The novel dihydroepiandrosterone derivatives, represented by formula (I), are prepared by bonding L-aspartate, L-asparagine or pyruvate to dihydroepiandrosterone via an ester linkage at the position 3 of dihydroepiandrosterone. The novel compounds have potent anti-osteoporosis activity with a suppression against side effects, such as liver enlargement, so that they can be used as agents for the prophylaxis and treatment of osteoporosis, applicable for clinical practice, wherein R is L-aspartate, L-asparagine or pyruvate.</p> |
