IMIDAZOLE COMPOUNDS AND THEIR USE AS ADENOSINE DEAMINASE INHIBITORS

摘要

Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R<1> is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent (s); R<2> is hydrogen or lower alkyl; R<3> is hydroxy or protected hydroxy; R<4> is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and -A- is -Q- or -O-Q-, wherein Q is single bond or lower alkylene, provided that when R<2> is lower alkyl, then R<1> is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.