NOVEL G PROTEIN-CONJUGATED RECEPTOR PROTEIN AND DNA THEREOF

摘要

A protein originating in human brain, its peptide fragment or salts thereof; a DNA encoding the above receptor protein; a process for producing the protein; a method for determining a ligand to the above G protein-conjugated receptor; a method for screening a compound capable of altering the binding of the ligand to the protein and a screening kit therefor; a compound obtained by the above screening method or its salt; an antibody against the above G protein-conjugated receptor protein, etc. The above-described G protein-conjugated receptor protein originating in human brain or the DNA encoding the same is useful: (1) in determining a ligand; (2) in acquiring an antibody and an antiserum; (3) in constructing an expression system of a recombinant receptor protein; (4) in developing a receptor-binding assay system and screening a candidate for a drug with the use of the above expression system; (5) in designing a drug on the basis of a comparison with a ligand receptor having a similar structure; (6) as a reagent in constructing probes, PCR primers, etc. in gene diagnosis; (7) in constructing a transgenic animal; (8) as a drug such as a genetic preventive/remedy.