Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline receptor in an amount effective to bind to said receptor, wherein said bis-benzene contains at least one amidine group (e.g., one or two). The contacting step may be carried out in vivo or in vitro. Contacting may be carried out with individual active compounds or with libraries of active compounds.
申请公布号
WO0004893(A2)
申请公布日期
2000.02.03
申请号
WO1999US14428
申请日期
1999.06.25
申请人
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;TIDWELL, RICHARD, R.;HALL, JAMES, E.;WOOD, DOROTHY, H.
发明人
TIDWELL, RICHARD, R.;HALL, JAMES, E.;WOOD, DOROTHY, H.