发明名称 |
DILTIAZEM CONTROLLED RELEASE FORMULATION AND METHOD OF MANUFACTURE |
摘要 |
A controlled release diltiazem dosage formulation comprising a plurality of active pellets coated with an extended release coating wherein the active pellets contain diltiazem or a pharmaceutically acceptable salt, a pharmaceutically acceptable inert seed and a binder and the extended release coating contains a water insoluble water permeable polymer, a channeling agent, a lubricant and optionally a surfactant. A single batch intermittent method of manufacturing a heterogeneous population of extended release pellets for use as a dosage formulation is also disclosed.
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申请公布号 |
WO0004883(A1) |
申请公布日期 |
2000.02.03 |
申请号 |
WO1999US12375 |
申请日期 |
1999.07.16 |
申请人 |
ANDRX PHARMACEUTICALS, INC. |
发明人 |
CHEN, CHIH-MING;CHENG, XIU, XIU;JAN, STEVE |
分类号 |
A61K9/50;A61K9/52;A61K9/54;A61K9/58;A61K9/62;A61K31/554;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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