摘要 |
<p>PCT No. PCT/JP94/01042 Sec. 371 Date Jun. 24, 1996 Sec. 102(e) Date Jun. 24, 1996 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/00537 PCT Pub. Date Jan. 5, 1995A compound of the formula: <IMAGE> in which R4 is acyl, R5 is lower alkyl, R6 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl, R7 is lower alkyl or lower alkylthio(lower)alkyl, R8 is carboxy or protected carboxy, A is lower alkylene, Z is a group of the formula: <IMAGE> wherein R1 is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl, R2 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, and R3 is optionally substituted heterocyclic(lower)alkyl, and m is an integer of 0 to 2, or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.</p> |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
HEMMI, KEIJI;NEYA, MASAHIRO;FUKAMI, NAOKI;KAYAKIRI, NATSUKO;TANAKA, HIROKAZU |