PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS

摘要

Compounds of formula (I), or a salt thereof, wherein A and B independently represent hydrogen, halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6 alkyl or C1-6 alkoxy; X and Y independently represent hydrogen, halogen, trifluoromethyl, trifluoromethoxy, C1-6 alkyl, C1-6 alkoxy or phenyl; and Q represents a substituted five-, six- or seven-membered monocyclic heteroaliphatic ring containing one nitrogen atom and optionally one other heteroatom selected from oxygen, sulphur and nitrogen; or Q represents a substituted 6- to 11-membered bicyclic heteroaliphatic ring system which contains one nitrogen atom as the sole heteroatom; the moiety Q being linked to the remainder of the molecule via a carbon atom are selective antagonists of the humain 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including psychotic disorders such as schizophrenia.