发明名称 |
SULTOPRIDE DERIVATIVE AND ANTI-SULTOPRIDE ANTIBODY |
摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound, that consists of a specific sultopride derivative having excellent specificity and useful for obtaining a useful reagent for immunologically determining sultopride in a biological sample such as serum or urine in a simple, speedily and accurately. SOLUTION: A compound expressed by formula I (L is a bonding group; X is a residue of an enzyme or a residue of a support material) is obtained by bonding a compound of formula II (R is a group capable of bonding to a support material or an enzyme directly or with a bonding agent) or its salt to a support material or an enzyme. For example, when X is a residue of a support material, the compound of formula I is obtained by converting the carboxyl group contained in the substituting group R in formula II into an active ester and condensing the obtained active ester with the amino group of the support material. A polyclonal antibody is obtained by immunizing an animal other than human using a compound of formula I whose X is a residue of a support material as an antigen. A reagent for determining sultopride is obtained from the obtained antibody and the compound of formula I whose X is a residue of a support material.
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申请公布号 |
JP2000034278(A) |
申请公布日期 |
2000.02.02 |
申请号 |
JP19980219807 |
申请日期 |
1998.07.17 |
申请人 |
DAINIPPON PHARMACEUT CO LTD |
发明人 |
KATSUZAKI TOMOYUKI;TAKEI YOSHIFUMI;YASHIKI TETSUYA;FUNAOKA HIROYUKI;SHIRAI AKIKO;OKARU YASUHIKO;KATO SHIROU;ISHII YASUO |
分类号 |
G01N33/53;A61K39/385;C07D207/09;C07K16/44;(IPC1-7):C07D207/09 |
主分类号 |
G01N33/53 |
代理机构 |
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